PEER-REVIEWED PUBLICATIONS
41. Lo N and Kim H. (2026) Tilting the balance of life and death: Navigating DNA replication stress in cancer therapy, Exp. Mol. Med. doi.org/10.1038/s12276-026-01745-9 (https://www.nature.com/articles/s12276-026-01745-9)
40. Choi YJ, Hwang S, Lee C, Zeng H, Chen X, Jo U, Kim H, Liu A, Park D, Wallingford J, Chen J. (2025) Identification of conserved residues essential for the ciliogenic functions of WDPCP. Dis Models Mech. 8(11):dmm052149. doi: 10.1242/dmm.052149
39. Khan A, Lim JF, Lo N, Patel JA, Haley J, Kim H. (2025) TIPIN coordinates ATM-dependent checkpoint and NF-kB signaling to counteract DNA replication damage from topoisomerase inhibition. Commun. Biol. doi.org/10.1038/s42003-025-09084-7
38. Park J, Rageul J, Lo N, Patel JA, Talos F, Kim H. (2025) Loss of DNA replication fork protection by TIMELESS degradation supports oncogene-induced senescence. Biochem. Biophys. Res. Commun., doi.org/10.1016/j.bbrc.2025.152203
37. Patel JA, Rageul J, Lo N, Nandi A, Zezelic C, Lee CT, Khan A, Kim H. (2025) The DNA-PKcs/JNK/p53 pathway underlies changes in cell fate decision toward death during DNA replication catastrophe. Nucleic Acids Res. doi/org/10.1093/nar/gkaf573
36. Saldanha J, Rageul J, Patel JA, Phi AL, Lo N, Park JJ, Kim H. (2024) The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation. Nucleic Acids Res. doi: 10.1093/nar/gkae445
35. Rageul J, Lo N, Phi AL, Patel JA, Park JJ, Kim H. (2024) Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection. Cell Reports. doi.org/10.1016/j.celrep.2024.113845
34. Saldanha J, Rageul J, Patel JA, Kim H. (2023) The adaptive mechanisms and checkpoint responses to a stressed DNA replication fork. Int. J. Mol. Sci. 24(13), 10488, doi.org/10.3390/ijms241310488
33. Patel JA, Zezelic C, Rageul J, Saldanha J, Khan A, Kim H. (2023) Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe. Nucleic Acids Res. doi: 10.1093/nar/gkad363
32. Patel JA and Kim H. (2023) The TIMELESS effort for timely DNA replication and protection. Cell. Mol. Life Sci. doi.org/10.1007/s00018-023-04738-3
31. Weinheimer AS, Paung Y, Rageul J, Khan A, Lo N, Ho B, Tong M, Alphonse S, Seeliger M, Kim H. (2022) Extended DNA binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks. J. Biol. Chem. doi.org/10.1016/j.jbc.2022.102268
30. Lo N, Rageul J, Kim H. (2021) Roles of SDE2 and TIMELESS at active and stalled DNA replication forks Mol. Cell Oncol. 8(1):1855053. doi: 10.1080/
23723556.2020.1855053.
29. Rageul J, Park JJ, Zeng PP, Lee E-A, Yang J, Hwang S, Lo N, Weinheimer AS, Schärer OD, Yeo J-E, Kim H. (2020) SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks. Nature Communications. doi.org/10.1038/s41467-020-19162-5
- Selected as a featured article at Editors' Highlights on Genomes and Epigenomes (https://www.nature.com/collections/bhkhbxstgj/content/anne-mirabella)
28. Nagareddy B, Khan A, Kim H. (2020) Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation. J. Biol. Chem. doi: 10.1074/jbc.RA120.015288
27. Soung Y, Chung H, Yan C, Fesler A, Kim H, Oh E-S, Ju J, Chung J. (2020) Therapeutic potential of chemically modified miR-489 in triple-negative breast cancers. Cancers, doi.org/10.3390/cancers12082209
26. Luo A, Gong Y, Kim H, Chen Y. (2020) Proteome dynamics analysis identifies functional roles of SDE2 and hypoxia in DNA damage response in prostate cancer cells. Nucleic Acids Res. Cancer, doi.org/10.1093/narcan/zcaa010
25. Rageul J and Kim H. (2020) Fanconi anemia and the underlying causes of genomic instability. Environ. Mol. Mutagen. doi.org/10.1002/em.22358
24. Darienzo RE, Wang J, Chen O, Sullivan M, Mironava T, Kim H, Tannenbaum R. (2019) Surface-Enhanced Raman Spectroscopy characterization of Breast cell phenotypes: effect of nanoparticle geometry, ACS Appl. Nano Mater., doi.org/10.1021/acsanm.9b0146
23. Rageul J, Weinheimer AS, Park JJ, Kim H. (2019) Proteolytic control of genome integrity at the replication fork, DNA Repair, doi:10.1016/j.dnarep.2019.
102657
22. Wang J, Chan B, Tong M, Paung Y, Jo U, Martin D, Seeliger M, Haley J, Kim H. (2019) Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway PLoS Genetics 15(2): e1007983
21. Rageul J, Park J, Jo U, Weinheimer AS, Vu T, Kim H. (2019) Conditional degradation of SDE2 by the Arg/N-end rule pathway regulates stress response at replication forks Nucleic Acids Research doi:10.1093/nar/gkz054
20. Jo U, Cai W, Wang J, Kwon Y, D'Andrea AD, Kim H. PCNA-dependent cleavage and degradation of SDE2 regulates response to replication stress (2016) PLoS Genetics 12(12): e1006465.
19. Li H, Lim KS, Kim H, Hinds TR, Jo U, Mao H, Weller CE, Sun J, Chatterjee C, D’Andrea AD, Zheng N. (2016) Allosteric activation of ubiquitin-specific proteases by β-propeller proteins UAF1 and WDR20 Molecular Cell 63(2):249-60
18. Wang J, Jo U, Joo S, Kim H. (2016) FBW7 regulates DNA interstrand cross-link repair by modulating FAAP20 degradation Oncotarget 14;7(24):35724-35740
17. Chen HC, Kanai M, Inoue-Yamauchi A, Tu HC, Huang Y, Ren D, Kim H, Takeda S, Reyna D, Chan P, Ganesan Y, Liao CP, Gavathiotis E, Hsieh JJ-D, Cheng EH-Y (2015) An interconnected hierarchical model of cell death regulation by the BCL-2 family. Nature Cell Biology 17(10):1270-81
16. Jo U and Kim H. (2015) Exploiting the Fanconi anemia pathway for targeted anti-cancer therapy Mol. Cells. 38(8): 669-676
15. Xie J, Kim H, Moreau LA, Puhalla S, Garber J, Muthana AA, Takeda S, D’Andrea AD. (2015) RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway, J. Clin. Invest. 125: 1523-1532
14. Wojtaszek J, Wang S, Kim H, Wu Q, D’Andrea AD, Zhou P. (2014) Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain. Nucleic Acids Research. 42: 13997-4005
13. Kim H, Dejsuphong D, Adelmant G, Ceccaldi R, Yang K, Marto JA, D’Andrea AD. (2014) Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. Molecular Cell 54:107-18
12. Park E, Kim H, Kim JM, Primack B, Vida-Cardenes S, Xu Y, Price BD, Mills A, D'Andrea AD. (2013) FANCD2 activates transcription of TAp63 and suppresses tumorigenesis. Molecular Cell 50: 908-18
11. Wojtaszek J, Lee CJ, D’Souza S, Minesinger B, Kim H, D’Andrea AD, Walker G, Zhou P. (2012) Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric Pol z and Pol k. J. Biol. Chem. 28: 33836-46
10. Kim H, and D’Andrea AD. (2012) Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes & Development 26: 1393-1408
9. Kim H, Yang K, Dejsuphong D, and D’Andrea AD. (2012) Regulation of Rev1 by the Fanconi anemia core complex. Nature Struct. Mol. Biol. 19: 164-170
8. Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ-D, and Cheng EH-Y. (2010) BID, BIM, and PUMA are essential for the BAX- and BAK-dependent cell death program. Science 330: 1390-1393
- Commented in Perspective, S.J. Martin (2010), Science 330: 1330-31
- Commented in Editor’s Choice (2010), Sci. Signal. 3, ec374
7. Kim H, Tu HC, Ren D, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ-D, Cheng EH-Y. (2009) Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Molecular Cell 36: 487-99
- Featured in Preview (2009), Mol. Cell 36:353-354
- Selected as an evaluated article in Faculty of 1000 (http://f1000.com/1229982)
6. Ren D, Kim H, Tu HC, Westergard TD, Fisher JK, Rubens JA, Korsmeyer SJ, Hsieh JJ-D, Cheng EH-Y. (2009) The VDAC2-BAK rheostat controls thymocyte survival. Science Signaling 2:ra48
5. Kim H, Hsieh JJ-D, Cheng EH-Y. Deadly splicing: Bax becomes almighty. (2009) Molecular Cell 33:145-6
4. Tu HC, Ren D, Wang GX, Chen DY, Westergard TD, Kim H, Sasagawa S, Hsieh JJ-D, Cheng EH-Y. (2009) The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Proc. Natl. Acad. Sci. USA.106: 1093-8
3. Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH-Y, Tjandra N, Walensky, LD. (2008) BAX activation is initiated at a novel interaction site. Nature 455: 1076-81
2. Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ-D, Cheng EH-Y. (2006) Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nature Cell Biology 8:1348-58
- Featured in News and Views (2006), Nat. Cell Biol. 8:1317-1319
- Selected as a collection of papers for “A decade of Nature Cell Biology” (2009)
1. Zerbinatti CV, Wahrle SE, Kim H, Cam JA, Bales K, Paul SM, Holtzman DM, Bu G. (2006) Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Aβ 42 accumulation in amyloid model mice. J. Biol. Chem. 281:36180-6
41. Lo N and Kim H. (2026) Tilting the balance of life and death: Navigating DNA replication stress in cancer therapy, Exp. Mol. Med. doi.org/10.1038/s12276-026-01745-9 (https://www.nature.com/articles/s12276-026-01745-9)
40. Choi YJ, Hwang S, Lee C, Zeng H, Chen X, Jo U, Kim H, Liu A, Park D, Wallingford J, Chen J. (2025) Identification of conserved residues essential for the ciliogenic functions of WDPCP. Dis Models Mech. 8(11):dmm052149. doi: 10.1242/dmm.052149
39. Khan A, Lim JF, Lo N, Patel JA, Haley J, Kim H. (2025) TIPIN coordinates ATM-dependent checkpoint and NF-kB signaling to counteract DNA replication damage from topoisomerase inhibition. Commun. Biol. doi.org/10.1038/s42003-025-09084-7
38. Park J, Rageul J, Lo N, Patel JA, Talos F, Kim H. (2025) Loss of DNA replication fork protection by TIMELESS degradation supports oncogene-induced senescence. Biochem. Biophys. Res. Commun., doi.org/10.1016/j.bbrc.2025.152203
37. Patel JA, Rageul J, Lo N, Nandi A, Zezelic C, Lee CT, Khan A, Kim H. (2025) The DNA-PKcs/JNK/p53 pathway underlies changes in cell fate decision toward death during DNA replication catastrophe. Nucleic Acids Res. doi/org/10.1093/nar/gkaf573
36. Saldanha J, Rageul J, Patel JA, Phi AL, Lo N, Park JJ, Kim H. (2024) The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation. Nucleic Acids Res. doi: 10.1093/nar/gkae445
35. Rageul J, Lo N, Phi AL, Patel JA, Park JJ, Kim H. (2024) Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection. Cell Reports. doi.org/10.1016/j.celrep.2024.113845
34. Saldanha J, Rageul J, Patel JA, Kim H. (2023) The adaptive mechanisms and checkpoint responses to a stressed DNA replication fork. Int. J. Mol. Sci. 24(13), 10488, doi.org/10.3390/ijms241310488
33. Patel JA, Zezelic C, Rageul J, Saldanha J, Khan A, Kim H. (2023) Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe. Nucleic Acids Res. doi: 10.1093/nar/gkad363
32. Patel JA and Kim H. (2023) The TIMELESS effort for timely DNA replication and protection. Cell. Mol. Life Sci. doi.org/10.1007/s00018-023-04738-3
31. Weinheimer AS, Paung Y, Rageul J, Khan A, Lo N, Ho B, Tong M, Alphonse S, Seeliger M, Kim H. (2022) Extended DNA binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks. J. Biol. Chem. doi.org/10.1016/j.jbc.2022.102268
30. Lo N, Rageul J, Kim H. (2021) Roles of SDE2 and TIMELESS at active and stalled DNA replication forks Mol. Cell Oncol. 8(1):1855053. doi: 10.1080/
23723556.2020.1855053.
29. Rageul J, Park JJ, Zeng PP, Lee E-A, Yang J, Hwang S, Lo N, Weinheimer AS, Schärer OD, Yeo J-E, Kim H. (2020) SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks. Nature Communications. doi.org/10.1038/s41467-020-19162-5
- Selected as a featured article at Editors' Highlights on Genomes and Epigenomes (https://www.nature.com/collections/bhkhbxstgj/content/anne-mirabella)
28. Nagareddy B, Khan A, Kim H. (2020) Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation. J. Biol. Chem. doi: 10.1074/jbc.RA120.015288
27. Soung Y, Chung H, Yan C, Fesler A, Kim H, Oh E-S, Ju J, Chung J. (2020) Therapeutic potential of chemically modified miR-489 in triple-negative breast cancers. Cancers, doi.org/10.3390/cancers12082209
26. Luo A, Gong Y, Kim H, Chen Y. (2020) Proteome dynamics analysis identifies functional roles of SDE2 and hypoxia in DNA damage response in prostate cancer cells. Nucleic Acids Res. Cancer, doi.org/10.1093/narcan/zcaa010
25. Rageul J and Kim H. (2020) Fanconi anemia and the underlying causes of genomic instability. Environ. Mol. Mutagen. doi.org/10.1002/em.22358
24. Darienzo RE, Wang J, Chen O, Sullivan M, Mironava T, Kim H, Tannenbaum R. (2019) Surface-Enhanced Raman Spectroscopy characterization of Breast cell phenotypes: effect of nanoparticle geometry, ACS Appl. Nano Mater., doi.org/10.1021/acsanm.9b0146
23. Rageul J, Weinheimer AS, Park JJ, Kim H. (2019) Proteolytic control of genome integrity at the replication fork, DNA Repair, doi:10.1016/j.dnarep.2019.
102657
22. Wang J, Chan B, Tong M, Paung Y, Jo U, Martin D, Seeliger M, Haley J, Kim H. (2019) Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway PLoS Genetics 15(2): e1007983
21. Rageul J, Park J, Jo U, Weinheimer AS, Vu T, Kim H. (2019) Conditional degradation of SDE2 by the Arg/N-end rule pathway regulates stress response at replication forks Nucleic Acids Research doi:10.1093/nar/gkz054
20. Jo U, Cai W, Wang J, Kwon Y, D'Andrea AD, Kim H. PCNA-dependent cleavage and degradation of SDE2 regulates response to replication stress (2016) PLoS Genetics 12(12): e1006465.
19. Li H, Lim KS, Kim H, Hinds TR, Jo U, Mao H, Weller CE, Sun J, Chatterjee C, D’Andrea AD, Zheng N. (2016) Allosteric activation of ubiquitin-specific proteases by β-propeller proteins UAF1 and WDR20 Molecular Cell 63(2):249-60
18. Wang J, Jo U, Joo S, Kim H. (2016) FBW7 regulates DNA interstrand cross-link repair by modulating FAAP20 degradation Oncotarget 14;7(24):35724-35740
17. Chen HC, Kanai M, Inoue-Yamauchi A, Tu HC, Huang Y, Ren D, Kim H, Takeda S, Reyna D, Chan P, Ganesan Y, Liao CP, Gavathiotis E, Hsieh JJ-D, Cheng EH-Y (2015) An interconnected hierarchical model of cell death regulation by the BCL-2 family. Nature Cell Biology 17(10):1270-81
16. Jo U and Kim H. (2015) Exploiting the Fanconi anemia pathway for targeted anti-cancer therapy Mol. Cells. 38(8): 669-676
15. Xie J, Kim H, Moreau LA, Puhalla S, Garber J, Muthana AA, Takeda S, D’Andrea AD. (2015) RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway, J. Clin. Invest. 125: 1523-1532
14. Wojtaszek J, Wang S, Kim H, Wu Q, D’Andrea AD, Zhou P. (2014) Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain. Nucleic Acids Research. 42: 13997-4005
13. Kim H, Dejsuphong D, Adelmant G, Ceccaldi R, Yang K, Marto JA, D’Andrea AD. (2014) Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. Molecular Cell 54:107-18
12. Park E, Kim H, Kim JM, Primack B, Vida-Cardenes S, Xu Y, Price BD, Mills A, D'Andrea AD. (2013) FANCD2 activates transcription of TAp63 and suppresses tumorigenesis. Molecular Cell 50: 908-18
11. Wojtaszek J, Lee CJ, D’Souza S, Minesinger B, Kim H, D’Andrea AD, Walker G, Zhou P. (2012) Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric Pol z and Pol k. J. Biol. Chem. 28: 33836-46
10. Kim H, and D’Andrea AD. (2012) Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes & Development 26: 1393-1408
9. Kim H, Yang K, Dejsuphong D, and D’Andrea AD. (2012) Regulation of Rev1 by the Fanconi anemia core complex. Nature Struct. Mol. Biol. 19: 164-170
8. Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ-D, and Cheng EH-Y. (2010) BID, BIM, and PUMA are essential for the BAX- and BAK-dependent cell death program. Science 330: 1390-1393
- Commented in Perspective, S.J. Martin (2010), Science 330: 1330-31
- Commented in Editor’s Choice (2010), Sci. Signal. 3, ec374
7. Kim H, Tu HC, Ren D, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ-D, Cheng EH-Y. (2009) Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Molecular Cell 36: 487-99
- Featured in Preview (2009), Mol. Cell 36:353-354
- Selected as an evaluated article in Faculty of 1000 (http://f1000.com/1229982)
6. Ren D, Kim H, Tu HC, Westergard TD, Fisher JK, Rubens JA, Korsmeyer SJ, Hsieh JJ-D, Cheng EH-Y. (2009) The VDAC2-BAK rheostat controls thymocyte survival. Science Signaling 2:ra48
5. Kim H, Hsieh JJ-D, Cheng EH-Y. Deadly splicing: Bax becomes almighty. (2009) Molecular Cell 33:145-6
4. Tu HC, Ren D, Wang GX, Chen DY, Westergard TD, Kim H, Sasagawa S, Hsieh JJ-D, Cheng EH-Y. (2009) The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Proc. Natl. Acad. Sci. USA.106: 1093-8
3. Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH-Y, Tjandra N, Walensky, LD. (2008) BAX activation is initiated at a novel interaction site. Nature 455: 1076-81
2. Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ-D, Cheng EH-Y. (2006) Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nature Cell Biology 8:1348-58
- Featured in News and Views (2006), Nat. Cell Biol. 8:1317-1319
- Selected as a collection of papers for “A decade of Nature Cell Biology” (2009)
1. Zerbinatti CV, Wahrle SE, Kim H, Cam JA, Bales K, Paul SM, Holtzman DM, Bu G. (2006) Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Aβ 42 accumulation in amyloid model mice. J. Biol. Chem. 281:36180-6
